There are three changes to the starting XV from the game against Italy with Keith Earls coming into the back line and Cian Healy and Rob Herring starting up front.
CJ Stander will win his 50th cap when he runs out in green on Sunday afternoon. He made his debut against Wales in 2016 and has notched up 60 points to date for Ireland.
Johnny Sexton captains the side and is again partnered at half-back by Jamison Gibson Park.
Robbie Henshaw and Garry Ringrose line out in midfield while Earls returns to the back three alongside James Lowe and Hugo Keenan.
Up front Healy and Herring are back in the the front row alongside Tadhg Furlong with James Ryan and Iain Henderson again packing down in the second row.
Tadhg Beirne and Will Connors line out alongside Stander in an unchanged back row.
Conor Murray returns from injury to take a place among the replacements alongside Ronan Kelleher, Dave Kilcoyne, Andrew Porter, Ryan Baird, Jack Conan, Billy Burns and Jordan Larmour.
The game is live on Virgin Media (ROI) and BBC (NI) and kicks off at 3.00pm on Sunday afternoon. You can also follow all the action in our Scotland v Ireland Live Match Centre – with exclusive content, in-game stats, live updates and more.
IRELAND Team & Replacements (v Scotland, 2021 Guinness Six Nations Championship, BT Murrayfield, Sunday, March 14, kick-off 3pm):
15. Hugo Keenan (UCD/Leinster) 9
14. Keith Earls (Young Munster/Munster) 91
13. Garry Ringrose (UCD/Leinster) 33
12. Robbie Henshaw (Buccaneers/Leinster) 50
11. James Lowe (Leinster) 5
10. Jonathan Sexton (St. Mary’s College/Leinster) (capt) 97
9. Jamison Gibson-Park (Leinster) 8
1. Cian Healy (Clontarf/Leinster) 107
2. Rob Herring (Ballynahinch/Ulster) 19
3. Tadhg Furlong (Clontarf/Leinster) 47
4. Iain Henderson (Academy/Ulster) 61
5. James Ryan (UCD/Leinster) 34
6. Tadhg Beirne (Lansdowne/Munster) 20
7. Will Connors (UCD/Leinster) 8
8. CJ Stander (Shannon/Munster) 49
16. Ronan Kelleher (Lansdowne/Leinster) 9
17. Dave Kilcoyne (UL Bohemians/Munster) 41
18. Andrew Porter (UCD/Leinster) 35
19. Ryan Baird (Dublin University/Leinster) 1
20. Jack Conan (Old Belvedere/Leinster) 18
21. Conor Murray (Garryowen/Munster) 88
22. Billy Burns (Ulster) 6
23. Jordan Larmour (St. Mary’s College/Leinster) 27